To Think or Not to Think: Synaptic Activity and Aβ Release

To Think or Not to Think: Synaptic Activity and Aβ Release

Accumulation of b-amyloid protein (Ab) in the extra-cellular space of the brain has been hypothesized to be a culprit in the pathogenesis of Alzheimer's disease. In this issue of Neuron, Cirrito et al. describe a series of experiments demonstrating that extracellular Ab levels are directly modulated by neuronal and syn-aptic activity. Alzheimer's disease, the most common form of demen-tia in th...

“ To Think , or Not to Think , That Is the Question ”

[To think or not to think, that is the question].

Two studies explored the effects of forget instructions on autobiographical memory at immediate test and following delays of either 12-13 months, or 3-4 months. Using the Autobiographical Think/No-Think procedure (cf., Noreen & MacLeod, 2013), 24 never-depressed participants (Study 1) first generated 12 positive and 12 negative autobiographical memories and associated cues. Participants were th...

To think or not to think: two pathways towards persuasion by short films on AIDS prevention.

Health messages are designed to stimulate an active cognitive process in those audiences generally with little involvement. The Elaboration Likelihood Model by Petty and Cacioppo sustains that subjects with high involvement and those with low involvement react differently to the persuasive message to which they are exposed. One efficient way to capture the attention of the low involvement audie...

Bilateral Cervical Lymphadenopathy- Need to Think Beyond Tuberculosis

Any patient with bilateral lymphadenopathy especially in Indian subcontinent is regarded as suffering from tuberculosis unless proved otherwise. This sometimes leads to unwarranted delay in correct diagnosis and management if there is ignorance regarding other rarer etiologies. Rosai-Dorfman Disease (RDD) may present in the same manner and should always be kept on the back of the mind to help a...